Potential of Ferritin-Based Platforms for Tumor Immunotherapy

Potential of Ferritin-Based Platforms for Tumor Immunotherapy

Blog Article

Ferritin is an iron storage protein that plays a key role in iron homeostasis and cellular antioxidant activity.Ferritin has many advantages as a tumor immunotherapy platform, including a small particle size that allows for penetration into tumor-draining lymph nodes Long Sleeve Tops or tumor tissue, a unique structure consisting of 24 self-assembled subunits, cavities that can encapsulate drugs, natural targeting functions, and a modifiable outer surface.In this review, we summarize related research applying ferritin as a tumor immune vaccine or a nanocarrier for immunomodulator drugs based on different targeting mechanisms (including dendritic cells, tumor-associated macrophages, tumor-associated fibroblasts, and tumor cells).In addition, a ferritin-based tumor vaccine expected to protect against a wide range of coronaviruses by targeting multiple variants of SARS-CoV-2 has entered phase I clinical trials, and its efficacy is described in this review.Although ferritin is already on the road to transformation, there are still many difficulties to overcome.

Therefore, three barriers (drug 8 Piece Sectional loading, modification sites, and animal models) are also discussed in this paper.Notwithstanding, the ferritin-based nanoplatform has great potential for tumor immunotherapy, with greater possibility of clinical transformation.